GPAT4 KNOCKOUT MOUSE
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UCLA Technology Available For Licensing |
INNOVATION:
Researchers at UCLA have developed a mouse strain genetically modified to interrupt (knock out) the gene for glycerol-3-phosphate acyltransferase 4 (GPAT4; originally known as AGPAT6). This mutant mouse model is a valuable tool for investigation of the physiological function of GPAT4 in lipid metabolism, obesity, diabetes and related disorders.
Related Papers (Selected)
- Beigneux AP, Vergnes L, Qiao X, Quatela S, Davis R, Watkins SM, Coleman RA, Walzem RL, Philips M, Reue K, Young SG. (2006) Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. J Lipid Res. 47(4):734-744. [more]
- Vergnes L, Beigneux AP, Davis R, Watkins SM, Young SG, Reue K. (2006) Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. J Lipid Res.;47(4):745-754. [more]
- Nagle CA, Vergnes L, Dejong H, Wang S, Lewin TM, Reue K, Coleman RA. (2008) Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice. J Lipid Res. 49(4):823-831. [more]
Reference: UCLA Case No. 2009-186
For additional technical details and current licensing
availability,
please contact the following UCLA office:
UCLA Office of Intellectual Property
11000 Kinross Avenue, Suite #200
Los Angeles, CA 90095
Tel: 310-794-0558 Fax: 310-794-0638
email: ncd@research.ucla.edu
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NCD URL: http://www.research.ucla.edu/tech/ucla09-186.htm
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UCLA Technologies Available for
Licensing
http://www.research.ucla.edu/oipa/industry
Copyright © 2008 The Regents of the
University of California.
keywords: mouse model, knockout, GPAT4, AGPAT6, glycerol-3-phosphate acyltransferase
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