BACKGROUND:  Radiochemicals have become a widespread tool for nuclear medicine imaging and in laboratory research. Synthesizing chemical molecules often includes multiple reaction steps and, depending on the reaction, intermediate purification steps. Making radioactively labeled compounds with minimum exposure to the chemist requires radiochemical steps to be carried out in an automated manner.

While systems that perform automated chemistry exist in the market, they are frequently designed with a particular reaction process in mind. It is therefore difficult to adapt existing systems to new reaction processes. There is a need for automated equipment that is both flexible and modular, allowing for the implementation of different types of purifications.

INNOVATION:  Researchers at UCLA have created a configurable module for cartridge purifications that is automated and that can be operated by remote control. Due to the wide variety of purifications that are performed in cartridges, there is enormous flexibility inherent in this standalone module. The system can be used as a stand-alone system or as a module that can be integrated into other fluidic systems. The remote interface is accessible via a program on a personal computer.

POTENTIAL APPLICATIONS 

• Method to purify and create chemical molecules, particularly where automation and/or remote control is desirable

ADVANTAGES

• Consistency of chemical reactions due to automation
• Reduces staff's exposure to radioactive material
• Low cost
• Simple interface

DEVELOPMENT-TO-DATE:  A prototype of the module is currently in use for creating two radiochemicals (both are PET tracers). Researchers have also completed the development of a stand-alone control interface with a microprocessor so that the remote control will no longer require a PC.

Reference: UCLA Case No. 2009-050