INNOVATION:  Researchers at UCLA have identified a novel family of five highly bioactive peptides with therapeutic implications in diseases such as diabetes and Alzheimer's. Experiments involving the 5 peptides have shown them to demonstrate anti-apoptotic actions in β-cells, neurons, and other cells, which may be useful in treatment of type-1, and type-2 diabetes. In addition, peptides 2 and 3 were shown to rescue neurons from Aβ-induced apoptosis, suggesting a possible preventative potential against Alzheimer's disease.

POTENTIAL APPLICATIONS 

• Systemic administration of these peptides to individuals suffering from neurodegenerative disease (Alzheimer's, Parkinson's, Huntington's), or diabetes (type 1 and 2) will ameliorate symptoms and the progression of the disease.

ADVANTAGES

• Novel composition of matter
• Potential new therapy for neurodegenerative diseases (Alzheimer's, Parkinson's, Huntington's), and type-1 and type-2 diabetes

DEVELOPMENT-TO-DATE:  The peptides have been tested in vitro (mouse NIT-1 insulinoma β-cells, 22RV1 human prostate cancer cells, and mouse primary cortical neurons). The exact mechanisms of action of the peptides have not yet been determined.

Reference: UCLA Case No. 2008-488