ANTIBODY MEDIATED GENE DELIVERY OF THE TUMOR SUPPRESSOR PROTEIN p53
|
UCLA Technology Available For Licensing |
BACKGROUND:
p53 plays a pivotal role towards inhibition of tumor progression, survival, and metastasis. As such, p53 has been a central target in tumor therapy and in particular, gene therapy targeting cancer. Recent efforts in utilizing p53 as a gene therapy show varying efficacies. The primary cause for these inconsistencies appears to be the inherit obstacles which gene therapy must overcome. Current approaches in gene therapy are hampered by inefficient delivery, toxicity concerns, immunogenicity, proper gene function, and limited expression of the gene delivered. Due to its potent tumor suppressing capacity, however, gene therapy with p53 continues to be one of the more sought after tumor therapies.
INNOVATION:
UCLA Researchers have developed a novel method to deliver functional p53 to tumor cells by fusion of p53 to the Fv peptide of a murine antibody (Fv-p53). This approach allows for delivery of p53 to tumor cells both in vitro and in vivo. Furthermore, Fv-p53 induces apoptosis in tumor cells in vitro and prevents metastasis of colon cancer in vivo. Therefore, Fv-p53 represents a novel protein (gene) therapy in cancer treatment.
POTENTIAL APPLICATIONS
- Tumor therapy for cancers involving p53
- Treatment of cancer metastasis
ADVANTAGES
- Receptor mediated delivery is not required
- Functional p53 is delivered intact, with no need for induction
- No toxicity from viral vectors
Related Papers (Selected)
- Antibody-Mediated p53 Protein Therapy Prevents Liver Metastasis In vivo. [read more]
Reference: UCLA Case No. 2007-250
For additional technical details and current licensing
availability,
please contact the following UCLA office:
UCLA Office of Intellectual Property
11000 Kinross Avenue, Suite #200
Los Angeles, CA 90095
Tel: 310-794-0558 Fax: 310-794-0638
email: ncd@research.ucla.edu
|
NCD URL: http://www.research.ucla.edu/tech/ucla07-250.htm
|
UCLA Technologies Available for
Licensing
http://www.research.ucla.edu/oipa/industry
Copyright © 2007 The Regents of the
University of California.
keywords: p53, gene therapy, tumor therapy, cancer therapy therapeutics
uclancd ucla latest inventions technology top ten 10 technologies intellectual property patents technology transfer invention business card