NATURAL RELEASE OF PEPTIDES THAT INHIBIT FOOD INTAKE
UCLA Technology Available For Licensing

BACKGROUND:  Peptides that contribute to a feeling of fullness after consuming a meal include cholecystokinin, Protein YY and Glucagon-like peptide 1 (GLP-1). Currently, administration of these satiety peptides for weight loss requires injection and results in non-physiological levels of satiety peptide with potential adverse side effects. A less invasive way to stimulate satiety peptide release without caloric intake would be a novel therapeutic approach for weight loss.

INNOVATION:  UCLA researchers have discovered a natural method to induce the release of multiple satiety peptides at physiologically relevant levels. This invention includes oral administration of a combination of two agents that stimulates the release of multiple satiety peptides. Researchers have shown the effectiveness of the invention in rats and are interested in moving the invention into clinical trials.

POTENTIAL APPLICATIONS 

ADVANTAGES

Selected Paper

Chelikani PK, Haver AC, Reeve JR, Keire DA, Reidelberger RD. Am J Physiol Regul Integr Comp Physiol. 2006 Feb;290(2):R298-305. (Link)

Reference: UCLA Case No. 2007-106

For additional technical details and current licensing
availability, please contact the following UCLA office:

UCLA Office of Intellectual Property
11000 Kinross Avenue, Suite #200
Los Angeles, CA 90095-7231
Tel: 310-794-0558 Fax: 310-794-0638
email: ncd@research.ucla.edu
NCD URL:   http://www.research.ucla.edu/tech/ucla07-106.htm

Lead Inventor: Joseph Reeve

UCLA Technologies Available for Licensing
http://www.research.ucla.edu/oipa/industry

Copyright © 2006 The Regents of the University of California.

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