MOUSE MODEL DEFICIENT FOR THE PROTON SENSING GPCR T-CELL DEATH-ASSOCIATED GENE 8 (TDAG)

MOUSE MODEL DEFICIENT FOR THE PROTON SENSING GPCR T-CELL DEATH-ASSOCIATED GENE 8 (TDAG)

UCLA Technology Available For Licensing

BACKGROUND: T-cell death-associated gene 8 (TDAG8) functions as a proton sensing GPCR. TDAG8 was originally proposed to bind pro-inflammatory lipids. More recent studies have challenged the identification of lipid agonists for TDAG8 and have suggested that it functions mainly as a proton sensor.

INNOVATION: Researchers at UCLA have developed a mouse model deficient for TDAG8. It was confirm by using this model that the inactivation of TDAG8 proton sensor abolishes acid-induced production of the secondary messenger cyclic AMP in immune cells.

POTENTIAL APPLICATIONS: These TDAG8 deficient mice can be used to test the modulation of immune responses under acidic and pathological conditions such as inflammatory responses during infections, airway condensates from asthmatic patients, and microenvironments of many solid tumors, which are all accompanied by pH values as low as 5.5-7.0.

Reference: UCLA Case No. 2006-624

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