ANTI-MAGI-2 RABBIT POLYCLONAL ANTIBODY
UCLA Technology Available For Licensing

BACKGROUND:  The MAGI-2 membrane protein (membrane-associated guanylate kinase inverted 3) acts as a scaffold to interact directly with and regulate the stability of both PTEN and IRSp53. In addition, members of the MAGI protein family are known to cluster receptors, signaling, and scaffolding proteins at specific membrane regions, including tight and synaptic junctions thereby playing important roles in regulating cell adhesion and signaling.

INNOVATION:  UCLA researchers have developed polyclonal antibodies that recognize human MAGI-2, in addition to the mouse and rat MAGI-2 homologues (mouse AIP-1 and rat S-SCAM). Importantly, the antisera does not interact with closely related proteins MAGI-1 and MAGI-3. The anti-MAGI-2 antibodies have been successfully used for immunoblotting, immunoprecipitation, and immunofluorescence experiments, performing much better than other commercially available antibodies.

POTENTIAL APPLICATIONS 

Reference: UCLA Case No. 2006-594

For additional technical details and current licensing
availability, please contact the following UCLA office:

UCLA Office of Intellectual Property
11000 Kinross Avenue, Suite #200
Los Angeles, CA 90095-7231
Tel: 310-794-0558 Fax: 310-794-0638
email: ncd@research.ucla.edu
NCD URL:   http://www.research.ucla.edu/tech/ucla06-594.htm

Lead Inventor: Brian Skaggs

UCLA Technologies Available for Licensing
http://www.research.ucla.edu/oipa/industry

Copyright © 2007 The Regents of the University of California.

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