INNOVATION:  UCLA scientists have developed a new method and hardware add on to existing MRI/NMR probes to enhance the contrast of MR images. This method of enhancement, termed "avalanching amplification", is sensitive to small variations in versatile MR parameters. As a result, the technique can be used to distinguish subtle differences between pathologic and non-pathologic tissue. For example, cortical epileptogenic lesions and malignant brain tumors typically yield minimal contrast differences when using routine MRI. However, use of avalanching amplification in the imaging of these samples can yield a 20-fold improvement in contrast. Furthermore, a systematic study of epileptogenic lesion samples has shown a 6-fold improvement in gray/white matter contrast using the technique.

ADVANTAGES

• Avalanche amplification greatly improves the contrast of MR images. Previously difficult to detect physiological changes will be easier to distinguish.
• Unlike metal ion-based contrast techniques, avalanche amplification is non-toxic and does not need to be internalized by the patient.

POTENTIAL APPLICATIONS 

• Avalanching amplification can be used to enhance MRIs. Since MRIs can be used in a range of applications, clinicians as well as physical, chemical and biomedical scientists will find avalanching amplification useful.

Reference: UCLA Case No. 2006-328