INNOVATION:  Scientists at UCLA have established that some nanoparticles have natural antimicrobial effects. In vitro experiments have shown the particles to be effective against the bacterial species P. acnes, S. aureus and E. coli. This finding could have an immediate medical impact since nanoparticles have already been approved by the FDA for other medical purposes. In addition, the researchers have developed protocols for the preparation of the innately antimicrobial nanoparticles.

POTENTIAL APPLICATIONS 

• The highly profitable cosmetic industry could develop next-generation acne medications from antimicrobial nanoparticles.
• Superficial and systemic Staph infections could be managed via nanoparticles.
• Nanoparticles could be used to treat a plethora of E. coli infections.
• Oral, topical, or intravenous applications could be developed.
• The antimicrobial effects of nanoparticles could potentially be applied to other bacterial species.

ADVANTAGES

• Nanoparticles have been shown to have an innate antimicrobial effect.
• UCLA scientists have developed protocols for preparation of the particles.
• The FDA has already approved the use of nanoparticles for other medical applications.
• All the desirable properties of nanoparticles still apply (i.e., controlled, delayed release, small size, minimal side effects, low cost of production).

Reference: UCLA Case No. 2006-264

PCT Application: WO 2007/149868