INNOVATION:  UCLA researchers have developed a new approach to prevent and treat infection by Chlamydia trachomatis. The scientists developed an antibody against a host protein that the pathogen uses to infect a cell. Experiments in vitro demonstrate that blocking the protein with the antibody greatly impedes infection. In vivo studies are currently being performed.

The novelty of this invention lays in the identification of a host protein that is required for Chlamydia trachomatis infection. Current therapies target the pathogen itself. Thus using this antibody to block infection could lead to the first prophylaxis for Chlamydia, and possibly a new class of therapeutics as well.

POTENTIAL APPLICATIONS 

• A topically applied formula containing the antibody or peptide antigen could be developed to prevent and/or treat Chlamydia trachomatis infections. For example, an intravaginal or condom-coating ointment similar to a spermicide could be developed.
• Additionally, eye drops containing the antibody could be developed for the prevention and/or treatment of trachoma.

ADVANTAGES

• This is the first host-based molecule discovered to be involved in the entry of Chlamydia trachomatis.
• This invention allows for the development of preventative therapies; current therapies for Chlamydia treat active infections.

Reference: UCLA Case No. 2005-555

PCT Application: WO/2006/113526