METHOD OF USING CARBONIC ANHYDRASE IX AS A MOLECULAR MARKER FOR PREDICTING SURVIVAL IN ADVANCED RENAL CLEAR CELL CARCINOMA
UCLA Technology Available For Licensing

Renal cell carcinoma (RCC) accounts for 2% of adult cancers. One-third of patients who are diagnosed with RCC have evidence of metastatic disease at the time of diagnosis and up to half of those treated for localized disease eventually relapsed. The high mortality rate in RCC plus the poor prognosis for the metastatic form of the disease post a need for molecular markers that can both diagnose RCC early and predict outcome reliably in response to therapeutic interventions. In a clinical study involving 1,200 RCC patients, UCLA Researchers have identified a novel method of using Carbonic Anhydrase IX as a molecular marker associated with RCC disease progression and survival. The level of expression of the molecular marker, reflected by its immunochemical staining profile, correlated with response to treatment, clinical factors, pathological features and survival. Thus, Carbonic Anhydrase IX can be used as a diagnostic and prognostic marker for detecting RCC and response to therapeutic interventions, respectively.

Related Papers (Selected)
  • Carbonic Anhydrase IX is an Independent Predictor of Survival in Advanced Renal Clear Cell Carcinoma: Implications for Prognosis and Therapy more...


Reference: UCLA Case No. 2002-463 US Patent Application: 20050158809

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NCD URL:   http://www.research.ucla.edu/tech/ucla02-463.htm

Lead Inventor: Matthew Bui

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Copyright © 2002 The Regents of the University of California.

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