TCL1 TRANSGENIC MICE

TCL1 TRANSGENIC MICE

UCLA Technology Available For Licensing

BACKGROUND: TCL1 is a protooncogene overexpressed in many mature B cell lymphomas. TCL1 is also expressed in precursor T cells and absent by the CD4+ CD8+ stage of thymocyte development. In B cells, TCL1 is first expressed in pro-B cells, and is completely absent in memory B cells and plasma cells.

INNOVATION: UCLA researchers have developed a murine model in which a TCL1 transgene is overexpressed in both B and T cells. These transgenic mice develop Burkitt-like lymphoma and diffuse large B cell lymphoma at 4 months. This phenotype is accompanied by attendant Bcl-6 expression and mutated JH antibody gene segments. Interestingly, TCL1 is a more powerful initiator of B cell malignancies when compared to the low frequency of T cell malignancies with this model. This is mirrored in humans as >85% of human immune system malignancies are B cell derived.

POTENTIAL APPLICATIONS

Mouse model for immune system malignancies in B, T and granulocytes cells.
Mouse model for B-cell selection, development, maturation, antibody production and signaling responses through PI3-kinase pathways.
Mouse model for designing therapeutics against B-cell malignancies and preventing autoantibody production in autoimmune diseases.

Related Papers (Selected)

2002 99(22):14392-14397. Dysregulated TCL1 Promotes Multiple Classes of Mature B Cell Lymphoma. more...

Reference: UCLA Case No. 2002-274

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Tel: 310-794-0558 Fax: 310-794-0638

email: ncd@research.ucla.edu

NCD URL: http://www.research.ucla.edu/tech/ucla02-274.htm

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