VASOACTIVE INTESTINAL PEPTIDE (VIP) AND PEPTIDE HISTIDINE ISOLEUCINE (PHI) KNOCKOUT MICE
|
UCLA Technology Available For Licensing |
BACKGROUND:
VIP and PHI are expressed at high levels in the neurons of the suprachiasmatic nucleus, the area of the nervous system responsible for most circadian behavior, but their function in the regulation of circadian rhythms is unknown. In order to study the role of these peptides on the circadian system in vivo, a new mouse model was developed in which both VIP and PHI genes were disrupted by homologous recombination.
INNOVATION:
In a light-dark cycle, the knockout mice were indistinguishable from control mice. However, in constant darkness, the VIP/PHI-deficient mice exhibited pronounced abnormalities in their circadian system. The VIP/PHI-deficient mice also exhibited deficits in the response of their circadian system to light. Researchers conclude that VIP/PHI peptides are critically involved in both the generation of circadian oscillations as well as the normal synchronization of these rhythms to light.
POTENTIAL APPLICATIONS
- Research tool for the study of circadian rhythms
- Development of drugs that over come the phenotype observed in the VIP/PHI deficient mice
Related Papers (Selected)
- Disrupted circadian rhythms in VIP- and PHI-deficient mice.
Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R939-49. Epub 2003 Jul 10.
[more]
Reference: UCLA Case No. 2001-173
For additional technical details and current licensing
availability,
please contact the following UCLA office:
UCLA Office of Intellectual Property
11000 Kinross Avenue, Suite #200
Los Angeles, CA 90095
Tel: 310-794-0558 Fax: 310-794-0638
email: ncd@research.ucla.edu
|
NCD URL: http://www.research.ucla.edu/tech/ucla01-173.htm
|
UCLA Technologies Available for
Licensing
http://www.research.ucla.edu/oipa/industry
Copyright © 2008 The Regents of the
University of California.
keywords: research tools mouse models drug development
uclancd ucla latest inventions technology top ten 10 technologies intellectual property patents technology transfer invention business card