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Methods of Using Prophenins-Antibiotic Peptides
Participating UCLA Inventors:
Robert I. Lehrer, Vladimir N. Kokryakov, Sylvia S.L. Harwig
Peptide-based compounds containing multiple proline residues are useful as preservatives and in preventing, treating or ameliorating microbial infection, especially Gram-negative bacterial infection in animals and plants, in treating conditions characterized by the presence of LPS.
U.S. Patent No. 5,633,229
Issued: May 27, 1997
Synthetic Ganglioside Derivatives
Participating UCLA Inventor:
Stephan Ladisch
Synthetic compounds which are useful for suppressing an immune response are disclosed. Also presented are methods for suppressing an immune response in an animal and compositions of matter.
U.S. Patent No. 5,567,684
Issued: October 22, 1996
Method of Fabricating Quantum Bridges by Selective Etching of Superlattice Structures
Participating UCLA Inventors:
Martin Tanner, Kang L. Wang
A quantum bridge structure including wires of a semiconductor material such as silicon which are formed by selectively etching a superlattice of alternating layers of at least two semiconductor materials. A quantum bridge structure may be useful as a photo emission device, a photo detector device, or a chemical sensor.
U.S. Patent No. 5,630,905
Issued: June 20, 1997
Screening Assay for Anti-HIV Drug Using the Vpr Gene
Participating UCLA Inventors:
Irvin S.Y. Chen, Jeremy B.M. Jowett, Vicente Planelles
The HIV-1 gene Vpr causes T-cells to cease dividing. Recognition of this role permits assay for potential drug candidates by virtue of their ability to interfere with the interaction of Vpr with its intracellular targets. The ability of a candidate to enhance the growth of a culture producing Vpr indicates its potential as an anti-HIV therapeutic.
U.S. Patent No. 5,639,619
Issued: June 17, 1997
Use of Taxol in the Treatment
of Rheumatoid Arthritis
Participating UCLA Inventor:
Ernest Brahn
An improved method of suppression of a progressive, inflammatory, autoimmune arthritis in a mammal involves the use of the drug Taxol. In general, such a method consists of administering to a mammal having or susceptible to arthritis. Taxol is a pharmacologically acceptable carrier capable of solubilizing Taxol in a dose sufficient to suppress at least one symptom of arthritis selected from this group of inflammation, swelling, abnormal neobvascularization, bone erosion, and cartilage erosion.
U.S. Patent No. 5,583,153
Issued: December 10, 1996
Treatment of Pancreatic Tumors With Peptide YY and Analogs Thereof
Participating UCLA Inventor:
David W. McFadden
A method of inhibiting proliferation of pancreatic tumors. The method involves contacting the pancreatic tumor with an effective amount of peptide YY or an analog of peptide YY. The method may be used in vitro or in vivo to reduce tumor cell proliferation. The method is also effective in treating both benign and malignant tumors.
U.S. Patent No. 5,574,010
Issued: November 12, 1996
Helicobacter Pylori Bacterial
Derived Factor
Participating UCLA Inventors:
Joseph R. Reeve, Peter A. Anton,
Kym Francis Faull, John H. Walsh
Chemotactin, diethyl phthalate, is shown to be a chemoattractant secreted by H. pylori. Chemotactin attracts phagocytic cells with a resulting inflammatory episode. Chemotactin and its metabolites may be used for diagnosis and monitoring courses of infection by H. pylori or other chemotactin secreting organisms.
U.S. Patent No. 5,547,844
Issued: August 20, 1996
Electromagnetically Actuated Micromachined Flap
Participating UCLA Inventors:
Chih-Ming Ho, Denny K. Miu,
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Jeremy Tzong-Shyng Leu
A surface micromachined micromagnetic actuator is provided with a flap capable of achieving large deflections above 100 microns using magnetic force as the actuating force.
U.S. Patent No. 5,629,918
Issued: May 13, 1997
Gene Mutation in Patients with Idiopathic Dilated Cardiomyopathy
Participating UCLA Inventors:
Luyi Sen, Aldons J. Lusis,
Kenneth D. Philipson
A genetic mutation within the SR calcium release channel provides a test for susceptibility to idiopathic dilated cardiomyopathy. The test detects the presence of the mutation in a sample of nucleic acids obtained from the individual being tested.
U.S. Patent No. 5,639,614
Issued: June 17, 1997
Detachable Endovascular
Occlusion Device Activated by Alternating Electric Current Participating UCLA Inventors:
Cheng Ji, Guido Guglielmi
An apparatus is provided for electrocoagulating blood and tissue at an occlusion site by means of application of an alternating signal or current through a detachable coil on the end of a microcatheter.
U.S. Patent No. 5,569,245
Issued: October 29, 1996
Endovascular Electrolytically Detachable Wire and Tip for the Formation of Thrombus in Arteries, Veins, Aneurysms, Vascular Malformations and Arteriovenous Fistuals
Participating UCLA Inventor:
Guido Guglielmi
An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity.
U.S. Patent No. 5,540,680
Issued: July 30, 1996
Reduced and Controlled Surface Binding of Biologically
Active Molecules
Participating UCLA Inventors:
Nir Kossovsky, Edward E. Sponsler, Andrew Gelman
Articles of manufacture which are adapted for use in contact with one or more biologically active agents are coated with a glassy carbohydrate film. The glassy film provides a reduced surface energy coating which exhibits a reduced degree of binding with biologically active agents.
U.S. Patent No. 5,639,505
Issued: June 17, 1997
Method for Producing Secretable Glycostyl Transferases and Other Golgi Processing Enzymes
Participating UCLA Inventors:
Eryn Ujita-Lee, James C. Paulson, Karen J. Colley, Jasminder Weinstein
A method for genetically engineering cells to produce soluble and secretable Golgi processing enzymes instead of naturally occurring membrane-bound enzymes. Cells are genetically engineered to express glycosyltransferases which lack both a membrane anchor and a retention signal.
U.S. Patent No. 5,541,083
Issued: July 30, 1996
Bio-Electronic Devices
Participating UCLA Inventors:
Nir Kossovsky, H. James Hnatyszyn, Samir Rajguru, Andrew Gelman
Improved bio-electronic devices in which a layer of a polyhydroxy oligomer is provided between the surface of a semiconductor material and an electronically active biochemical molecule which is designed to be bound to the semiconductor surface to provide an electronic device.
U.S. Patent No. 5,585,646
Issued: December 17, 1996
Methods and Compositions for Detecting Human Tumors
Participating UCLA Inventors:
Dennis J. Slamon, Martin J. Cline
Methods and compositions for detecting the presence of tumors are provided, where a physiological sample is assayed for the expression product of a c-onc gene as diagnostic for the presence of the tumor. The method finds use in both pre-and postoperative situations with a host suspected of having transformed malignant cells.
U.S. Patent No. RE35,491
Issued: April 8, 1997
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