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Endovascular Electrolytically Detachable Wire and Tip for the Formation of Thrombus in Arteries, Veins, Aneurysms, Vascular Malformations and Arteriovenous Fistulas
Participating UCLA Inventor:
Guido Guglielmi
A microcatheter system is used for the insertion of a platinum tip into the vascular cavity to obstruct blood flow or access of blood in the cavity, promoting blood clotting and the consequent formation of an occlusion. The tip can be left embedded into the thrombus, and ground electrodes are used to facilitate electrothrombosis.
U.S. Patent No. 5,855,578
Issued: January 5, 1999

Macromolecular Structure for Boron Neutron Capture Therapy
Participating UCLA Inventors:
Robert R. Kane, M. Frederick Hawthorne
This invention is a general synthetic method for the rapid and efficient production of a variety of boron-rich macro-molecules suitable for conjugation with or inclusion in receptor-mediated delivery systems, as well as other delivery systems. Preparation techniques have been developed to yield precisely ordered oligophosphates that are soluble, hydrophilic, may be homogeneous, and may be prepared with a variety of functional groups.
U.S. Patent No. 5,856,551
Issued: January 5, 1999

Compositions and Methods for Producing Sialyltransferases
Participating UCLA Inventors:
James C. Paulson, Sorge Kelm, William Gillespie
Sialic acids are the terminal sugars of many carbohydrate groups present on glycoproteins, glycolipids, and oligosaccharides. Because of their terminal position, they play an important role in the biological function of numerous carbohydrate structures that are widely distributed in animal tissues. In this invention, UCLA researchers have isolated the DNA coding sequence for the conserved region of homology of sialytransferases, a family of enzymes that catalyze the transfer of sialic acid to the terminal position of carbohydrates. With the recombinant sialyltransferase expression system realized by this invention, it is possible to overcome the significant costs associated with the purification of naturally occurring sialyltransferases and to create novel forms of sialyltransferases.
U.S. Patent No. 5,858,751
Issued: January 12, 1999

Process for Producing 8-Fluoropurines
Participating UCLA Inventors:
Jorge R. Barrio, Nagichettiar Satymurthy, Mohammad Namavari, Michael E. Phelps
This invention involves an efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F2 in He or other inert gas.
U.S. Patent No. 5,861,503
Issued: January 19, 1999

Method for the Determination of Low Concentrations of Heavy Metals
Participating UCLA Inventors:
Donald E. Pagila, Stephan W. Renner, Misae Nakatani
This invention provides a highly effective method of determining very low-level concentrations of heavy metals such as lead, cadminum, mercury, and copper in body fluids. Ratios of d-5’-N/Pyr-5’-N activities, which display greater deviation and stronger correlation with blood-heavy metal concentration than absolute Pyr-5’-N activities alone, are utilized to provide a highly sensitive, internally controlled biomarker of low-level lead overburden, for example.
U.S Patent No. 5,871,947
Issued: February 16, 1999

Plasma Torch Having a Cooled Shield Assembly
Participating UCLA Inventors:
William A. Huhn, Richard D. Dickman
This invention provides a plasma torch assembly for receiving electrical energy from an electrical energy source and generating plasma in a gas from a gas source. Included is a structure to receive electrical energy from the electrical energy source and provide energy to generate a field in a space for the plasma, and a shield assembly about the space for the plasma to shield against energy from the plasma and transfer energy from the structure.
U.S. Patent No. 5,877,471
Issued: March 2, 1999

Dopant Activation of Heavily Doped Semiconductor by High Current Densities
Participating UCLA Inventors:
King-Ning Tu, Jia-Sheng Huang
Disclosed in the invention is a method of activating dopants in semiconductor material comprising the steps of supersaturating the semiconductor material with a dopant, and applying a high-density current to the supersaturated semiconductor material above a predetermined activation threshold. As a result, the supersaturated dopants in the semiconductor materials are activated.
U.S. Patent No. 5,882,953
Issued: March 16, 1999

Micromachined Hot-Wire Shear Stress Sensor
Participating UCLA Inventors:
Chih-Ming Ho, Jin-Biao Huang
A micromachined hot-wire anemometer having fast response times and higher sensitivities than conventional hot-wire anemometers is provided by micromachining doped polysilicon wires carried on silicon supports cantilevered from substrate, including one or more insulating layers disposed between this substrate and supports. The micromachined polysilicon hot-wire anemometer is fabricated using surface micromachining techniques.
U.S. Patent No. 5,883,310
Issued: March 16, 1999

Liposome Compositions for Boron Neutron Capture Therapy and Methods Thereof
Participating UCLA Inventors:
M. Frederick Hawthorne, Debra A. Feakes, Kenneth J. Shelly
The invention provides composition and methods to deliver free and liposome-encapsulated borane compounds, in therapeutically useful concentrations, to tumors for use in neutron capture therapy. The liposomal encapsulation allows the energy emitting borane compounds to be localized to tumor sites.
U.S. Patent No. 5,888,473
Issued: March 30, 1999

Prophenins – Antibiotic Peptides
Participating UCLA Inventors:
Vladimir N. Kokryakov, Sylvia S.L. Harwig, Robert I. Lehrer
Disclosed are peptide-based compounds characterized by approximately 79 amino acid residues with repeating decamer regions and a multiplicity of proline residues having antimicrobial and/or LPS binding activity. These compounds, designated prophenins, are useful in preventing, treating or ameliorating microbial infection, primarily against Gram-negative bacteria that can cause LPS-induced septic shock. Also provided are recombinant materials for the production of these peptides.
U.S. Patent No. 5,889,152
U.S. Patent No. 5804,553
Issued: March 30, 1999
Issued: September 8, 1998

Ion-Implanted Protein-Coated Intralumenal Implants
Participating UCLA Inventors:
Yuichi Murymama, Fernando Vinuela
Ion-implanted protein-coated occlusion coils are described that have essentially the same dimensions as untreated coils and exhibit altered surface properties – e.g., thrombogenicity, endothelial cellular migration and adhesion – relative to untreated coils, thus making them particularly useful in treating wide-necked brain aneurysms.
U.S. Patent No. 5,891,192
Issued: April 6, 1999

Embolic Material for Endovascular Occlusion of Abnormal Vasculature and Method for Using the Same
Participating UCLA Inventors:
Guido Guglielmi, Cheng Ji
This invention is an endovascular embolic composition comprised of a hydrophilic insoluble matrix having a microscopic mesh-like structure. The voids or intricacies of the matrix enclose droplets of aqueous solution as well as liquid oil. This structure is essentially equivalent to a “gel” structure, with the insoluble matrix including both aqueous and oil droplets within its mesh.
U.S. Patent No. 5,894,022
Issued: April 13, 1999

Method of Using Clot Capture Coil
Participating UCLA Inventors:
Jeffrey P. Wensel, Y. Pierre Gobin
Described in the invention are methods to use a coil-type device to remove clots and foreign bodies in a vessel such as those produced in thromoemobolic disorders. Specifically, an elastic or superelastic coil, having shape memory, is inserted into the lumen of a catheter and used to clot a vessel. Removal of the catheter removes the clot. The device can also be used to obstruct and remove foreign bodies such as thromboemboli.
U.S. Patent No. 5,895,398
Issued: April 20, 1999

Method for Aligning and Forming Microelectromechanical Systems (Mems) Contour Surfaces
Participating UCLA Inventors:
Chih-Ming Ho, Wen J. Li
The invention is a method of fabricating micron-sized devices onto a contour surface comprising the steps of fabricating a patterned mask on a flexible substrate; disposing a photoresist layer onto a contour substrate; aligning the flexible mask conformally on the contour substrate; and exposing the mask and the photoresist on the contour substrate to a developing field of energy so that selected portions of the photoresist on the contour substrate are developed, thereby transferring the pattern from the mask to the photoresist layer on the contour substrate.
U.S. Patent No. 5,905,007
Issued: May 18, 1999

Method to Prevent Explosions in Fuel Tanks
Participating UCLA Inventor:
C. Kumar Patel
This invention involves a method for preventing explosions in closed tanks that hold flammable liquids and flammable vapors and air above these liquid fuels, comprising filling the ullage with a pressurized gas that not only excludes oxygen from the ullage but also prevents transmission of fire-initiating sparks. The method further comprises filling the ullage with an electronegative gas, alone or in combination with an inert gas or gases. More specifically, the preferred electronegative gas is sulfur hexafluoride (SF6), which may also be used in combination with CO2 and/or N2.
U.S. Patent No. 5,904,190
Issued: May 18, 1999

Diphtheria Toxin Vaccines Bearing a Mutated R Domain
Participating UCLA Inventors:
David Eisenberg, Seunghyon Choe
Diphtheria toxin polypeptides comprising a mutant R binding domain exhibit reduced target cell binding and may be used as vaccines to immunize a mammal against infection by Cornebacterium diptheria.
U.S. Patent No. 5,917,017
Issued: June 29, 1999

Apparatus and Method for the Use of Detachable Coils in Vascular Aneurysms and Body Cavities
Participating UCLA Inventor:
Guido Guglielmi
The retention of free coils or GDC coils within body cavities or aneurysms in the human vascular system is achieved through the use of a GDC cage. The GDC cage is comprised of an expandable cage coupled to the wire, with the cage and wire being disposed within a catheter. The cage has a memory so that it normally assumes an expanded configuration when unconfined, but is capable of assuming a collapsed configuration when disposed and confined. The cage may be used as a fishing tool to capture escaped free coils in the vessel, which may have escaped for the aneurysm.
U.S. Patent No. 5,916,235
Issued: June 29, 1999