Acquisition of Video Images Simultaneously with Analog Signals
Participating UCLA Researchers: David M. Rector, Ronald M. Harper A system for interleaving multiple analog signals with digital video camera images, permitting extensive, simultaneous monitoring of physiological signals in conjunction with real-time video images.
U.S. Patent No. 5,517,251
Issued: May 14, 1996

Allelic Association of the Human Dopamine (D2) Receptor Gene in Compulsive Disorders
Participating UCLA Researcher: Ernest P. Noble Methods for detecting a genetic trait that is disproportionately represented in individuals having compulsive disorders such as alcoholism and opiate addiction.
U.S. Patent No. 5,500,343
Issued: March 19, 1996

Analog Current Mode Analog/Digital Converter
Participating UCLA Researcher: Khayrollah Hadidi A new successive-approximation analog-to-digital (A/D) converter that employs a unique circuit configuration so that high conversation rate is achieved without a large chip area.
U.S. Patent No. 5,489,904
Issued: February 6, 1996

Biochemically Active Agents for Chemical Catalysis and Cell Receptor Activation
Participating UCLA Researchers: Nir Kossovsky, Andrew E. Gelman, Edward E. Sponsler, Samir Rajguru
U.S. Patent No. 5,460,830
Issued: October 24, 1995

Biological and Pharmaceutical Agents Having a Nanomeric Biodegradable Core
Participating UCLA Researchers: Nir Kossovsky, H. James Hnatyszyn, Andrew E. Gelman U.S. Patent No. 5,462,751
Issued: October 31, 1995

Biologically Active Compositions Having a Nanocrystalline Core
Participating UCLA Researchers: Nir Kossovsky, Rointan F. Bunshah
U.S. Patent No. 5,462,750
Issued: October 31, 1995
Above three patents relate to a conjugation system for proteins, peptides and pharmacologically active compounds that anchors these compounds to modified core particles in an active state, enabling the conjugated compounds to function normally in biologically reactive pairs for a wide variety of enzymatic and immunological interactions.

Cloned Glutamic Acid Decarboxylase Peptides
Participating UCLA Researchers: Allan J. Tobin, Mark G. Erlander, Daniel L. Kaufman, Michael J. Clare-Salzler The manipulation of genetic materials by recombinant procedures to produce polypeptides possessing part or all of the primary structural conformation of one or more antibody-binding epitopes of glutamic acid decarboxylase65 (GAD65). Useful for autoimmune diseases.
U.S. Patent No. 5,475,086
Issued: December 12, 1995

High-Efficiency, High-Power Multiquantum Well IMPATT Device with Optical Injection Locking
Participating UCLA Researchers: Charles C. Meng, Harold R. Fetterman High-power, low-noise, high-frequency source with application in air-traffic control radars, communications systems and modern weapons.
U.S. Patent No. 5,466,965
Issued: November 14, 1995

Information Storage and Processing
Participating UCLA Researchers: Han Huang, Craig A. Marioka, Osman Ratib, Paul N.S. Cho, Bruce K.T. Ho Convenient high-density, mobile and very efficient system for the storage of various medical records such as X-rays. Compatible with older and newer systems for storage.
U.S. Patent No. 5,471,606
Issued: November 28, 1995

Mammalian Antibiotic Peptides
Participating UCLA Researchers: Robert I. Lehrer, Vladimir N. Kokryakov, Sylvia S.L. Harwig Describes peptide compositions, 18-20 amino acids in length, having broad spectrum antimicrobial activity.
U.S. Patent No. 5,464,823
Issued: November 7, 1995

Method for Decreasing Calcium Uptake by Cells Using Selected Polycations
Participating UCLA Researchers: Glenn A. Langer, Jonathan R. Clague, Jan A. Post Describes highly cationic compositions that inhibit cellular uptake of calcium through calcium "leak channels." Potential applications in the preservation of oxygen-starved heart muscle cells immediately following a heart attack.
U.S. Patent No. 5,459,126
Issued: October 17, 1995

Method for Determining Favorable Prognosis in an HIV-Positive Subject Using HLA-DR+/CD38-/CD8bright Cells
Participating UCLA Researchers: Janis V. Giorgi, Lance Hultin The elevated presence of a subset of cells displaying certain lymphocyte cell surface markers correlates with favorable outcomes in HIV-infected subjects. The invention teaches methods for measuring such cell populations.
U.S. Patent No. 5,470,701
Issued: November 28, 1995

Method for Treating Gram-Negative Bacterial Infections in Humans
Participating UCLA Researcher: Lowell S. Young Uses a monoclonal antibody to the bacterial endotoxin in conjunction with an antibiotic.
U.S. Patent No. 5,484,591
Issued: January 16, 1996

Method of Growing Cells in a Mammal
Participating UCLA Researchers: Sanford Barsky, Mark Sternlicht A method of growing a human basement membrane composition ("Humatrix"), which is useful for growing and studying tumors and their reaction to various agents.
U.S. Patent No. 5,508,188
Issued: April 16, 1996

Method to Identify Protein Sequences that Fold into a Known Three-Dimensional Structure
Participating UCLA Researchers: David Eisenberg, James U. Bowie, Roland Luthy A computer-assisted method for identifying protein sequences that fold into a known three-dimensional structure. Establishes a link between known three-dimensional structures of proteins and target amino acids sequences in a way that simulates the malleability of real proteins.
U.S. Patent No. 5,436,850
Issued: July 25, 1995

Method to Treat Kaposi's Sarcoma
Participating UCLA Researchers: Steven A. Miles, Ronald H. Stevens, Otoniel M. Martinez, David Klashman Formulations and treatment protocols for the management of Kaposi's sarcoma.
U.S. Patent No. 5,470,824
Issued: November 28, 1995

Microwave Noncontact Identification Transponder Using Subharmonic Interrogation and Method of Using the Same
Participating UCLA Researchers: Carl W. Pobanz, Tatsuo Itoh A credit-card-sized identification device that employs solid-state circuits integrated with printed antennas. Applications include remote identification for security, toll collection and inventory control.
U.S. Patent No. 5,525,993
Issued: June 11, 1996

Polypeptide Having an Amino Acid Replaced with N-Benzylglycine
Participating UCLA Researcher: Alexander Mitchell Technique for replacement of selected amino acids with non-naturally occurring forms of selected amino acids within a biologically active polypeptide that has been synthesized by the Merrifield solid-phase method.
U.S. Patent No. 5,527,882
Issued: June 18, 1996

Production of Fullerenes by Sputtering
Participating UCLA Researchers: Rointan F. Bunshah, Shyankay Jou, Shiva Prakash, Hans J. Doerr A method for production of fullerenes utilizing the basic physical vapor deposition process commonly known as sputtering. Such a method can be used to efficiently control the important variables in the fullerene production process.
U.S. Patent No. 5,494,558
Issued: February 27, 1996

Programmable Digital Signal Processor Using Switchable Unit-Delays for Optimal Hardware Allocation
Participating UCLA Researchers: Alan N. Wilson Jr., Kei Y. Khoo, Alan Kwentus Integrated circuit provides Finite Impulse Response (FIR) digital filters and correlators that can be configured to meet any desired specification.
U.S. Patent No. 5,479,363
Issued: December 26, 1995

Red Blood Cell Surrogate
Participating UCLA Researchers: Nir Kossovsky, Andrew E. Gelman, H. James Hnatyszyn A red blood cell surrogate with oxygen-transport properties equivalent to natural RBCs. The surrogate consists of nanocrystalline core particles linked to oxygen carriers and other components.
U.S. Patent No. 5,464,634
Issued: November 7, 1995

Reduced and Controlled Surface Binding of Biologically Active Molecules
Participating UCLA Researchers: Nir Kossovsky, Andrew E. Gelman, Edward E. Sponsler Glassy carbohydrate film coating for implants used in vivo as containers, supports and transport elements, or for in-vitro materials in contact with biochemically active compounds. U.S. Patent No. 5,441,739
Issued: August 15, 1995

Semiconductor Bioelectronic Devices Incorporating Biochemical Stabilization Layers
Participating UCLA Researchers: Nir Kossovsky, Andrew E. Gelman, H. James Hnatyszyn, Samir Rajguru An improved bioelectronic semiconductor employing polyhydroxy oligomer layers to stabilize the electronically active biochemical component, protecting it against denaturization.
U.S. Patent No. 5,506,420
Issued: April 9, 1996

Synthesis of N-Formyl-3.4-DI-T-,Butoxycarbonyloxy-6-(Trimethylstannyl)-L-Phenylalanine Ethyl Ester and its Regioselective Radiofluorodestannylation to 6-[18F]Fluoro-1-Dopa
Participating UCLA Researchers: Nagichettiar Satyamurthy, Jorge R. Barrio, Allyson J. Bishop, Mohammad Namavari Synthesis of a tin-containing precursor for the preparation of Fluoro-L-dopa, a positron-emitting radiopharmaceutical used in positron emission tomography (PET) diagnostic procedures.
U.S. Patent No. 5,510,522
Issued: April 23, 1996

Targeted Transfection Nanoparticles
Participating UCLA Researchers: Nir Kossovsky, Andrew E. Gelman, H. James Hnatyszyn A composition consisting of core particles linked to DNA or RNA and targeting ligands, providing a system for targeted transfection of cells in gene therapy or other transfection procedures.
U.S. Patent No. 5,460,831
Issued: October 24, 1995