Compositions and Methods for the Identification and Synthesis of Sialyltransferases
Participating UCLA Researchers:
James Paulson, William Gillespie, and Sorge Kelm
This invention is a method of obtaining DNA isolates coding for sialytransferase. In addition, the expression systems for recombinant production of sialytransferase are determined.
U.S. Patent No. 5,962,294
Issued: October 5, 1999

Nucleic Acid Encoding Delta Opioid Receptor
Participating UCLA Researchers:
Christopher J. Evans, Duane E. Keith, Jr., and Robert H. Edwards
This invention provides recombinant materials and a method for producing mammalian delta opioid receptors. Other techniques also provided in the invention include methods for isolating the receptor, isolating the gene that encodes the receptor, recombinantly producing the receptor, and methods for using the receptor to screen for drugs that modulate the activity of the receptor.
U.S. Patent No. 5,985,600
Issued: November 16, 1999

Bipolar Transistor Having Base Region With Coupled Delta Layers
Participating UCLA Researchers:
Kang L. Wang, Timothy K. Carns, and Xinyu Zheng
This invention relates to semiconductor devices. Specifically this invention improves homojunction bipolar transistors and heterojunction bipolar transistors having a plurality of coupled delta doped layers in the base region.
U.S. Patent No. 5,965,931
Issued: October 12, 1999

Serum Immunoregulatory Polypeptide and Uses Therefor
Participating UCLA Researchers:
Yi-Han Chang, Edward Abraham
This invention relates to the discovery of previously undescribed and unisolated low molecular weight serum immunoregulatory polypeptides (SIPS) which are found in hemorrhagic mammalian blood. The SIPS regulate the immune response in mammals and thus have high potential in treating many conditions and diseases such as allograft rejection, auto-immunity, graft versus host diseases, allergies, cancer, and AIDS.
U.S. Patent No. 5,973,122
Issued: October 26, 1999

Ige Isoforms and Methods of Use
Participating UCLA Researchers:
Andrew Saxon, Sherie L. Morrison, Jeffrey B. Lyczak, and Ke Zhang
This invention provides methods and compositions for novel IgE isoforms and their use in immune hypersensitivity diagnosis and treatment. Transcription and translation products of the immunoglobulin epsilon locus, probes for epsilon transcription products, and compounds that bind to epitopes of epsilon translation products are included in the compositions. These products, probes, and binding compounds find use in methods and kits for immune hypersensitivity diagnosis and treatment.
U.S. Patent No. 6,043,345
Issued: March 28, 2000

Hybridomas and Monoclonal Antibodies that Specifically Bind to Glutamic Acide Decarboxylase Peptides
Participating UCLA Researchers:
Allan J. Tobin, Mark G. Erlander, Daniel Kaufman, and Michael Clare-Salzler
This invention relates to the discovery of isolated polypeptides in mitigating GAD-associated autoimmune diseases as well as diagnostic and therapeutic methods of using the peptides. Also disclosed in this invention are monoclonal antibodies specific for GAD peptides and hybridoma cells.
U.S. Patent No. 6,011,139
Issued: January 4, 2000

Method for Ameliorating Glutamic Acid Decarboxylase Associated Autoimmune Disorders
Participating UCLA Researchers:
Allan J. Tobin, Mark G. Erlander, and Daniel L. Kaufman
This invention involves manipulating genetic materials by recombinant DNA procedures. This allows for the production of polypeptides possessing part of all of the primary structural conformation for one or more of the epitopes for binding autoantibodies to glutamic acid decarboxylase65 (GAD65) and for polypeptides binding to MC receptors to block T-cell recognition.
U.S. Patent No. 5,998,366
Issued: December 7, 1999

Selective Inhibition of Internally Initiated RNA Translation
Participating UCLA Researchers:
Saumitra Das, Asim Dasgupta, and Peter Coward
This invention discloses a method to inhibit translation of mRNA. Translation of mRNA is inititated at the ribosome site of the mRNA and requires binding of a protein factor to that site. An inhibitory effective amount of a molecule that binds to the protein factor is provided in an in vivo or in vitro system. This prevents that particular protein factor from binding to the mRNA.
U.S. Patent No. 5,989,904
Issued: November 23, 1999

Endoluminal Ultrasound-guided Resectoscope
Participating UCLA Researchers:
Malcolm G. Munro
This invention is a surgical apparatus to allow the surgeon to accurately monitor the surgical procedure at all times. The apparatus includes both an endoscope and an ultrasound transducer, which permits the surgeon to monitor the surgery via visual as well as ultrasound techniques.
U.S. Patent No. 5,957,849
Issued: September 28, 1999

Detachable Endovascular Occlusion Device Activated by Alternating Electric Current
Participating UCLA Researchers:
Guido Guglielmi, Cheng Ji
This invention is an apparatus for electrocoagulating blood and tissue at an occlusion site by means of applying an alternating signal or current through a detachable partially insulated coil on the end of a microcatheter. A Guglielmi Detachable Coil (GDC) is recommended in combination with damped radio frequency to create local heating at the site of the coil, but without heated damaged tissue or hot spots.
U.S. Patent No. 5,976,131
Issued: November 2, 1999

Wearable Peritomeum-Based System for Continuous Renal Function Replacement and Other Biomedical Applications
Participating UCLA Researchers:
Martin Roberts, David Be-Nyi Lee
This invention is a wearable peritoneal dialysis device, which continually removes waste metabolites from the blood using a small volume (250-1000mls) of protein-containing dialysis with an overall flow rate of 2-3 liters per hour. The device may be worn on several locations on the torso and limbs. The device also provides hormones, nutrients, and therapeutic agents to the patient.
U.S. Patent No. 5,944,684
Issued: August 31, 1999

Use of Exochelins in the Preservation of Organs for Transplant
Participating UCLA Researchers:
Marcus A. Horwitz
This invention provides a method for administering exochelins to organs for transplant prior to or coincidental with the removal of those organs from the donor, storage, implantation in a recipient, or in conjunction with the re-establishment of flow of bodily fluids to the organ. Exochelins are used to prevent damage to organs for transplant. It prevents the formation or presence of the OH radical.
U.S. Patent No. 5,994,346
Issued: November 30, 1999

Preparation and Storage of Pancreatic Islets
Participating UCLA Researchers:
Yoko Mullen, Takashi Kenmochi
This invention provides a method for preparing and storing pancreatic islets for transplantation and diabetic patients.
U.S. Patent No. 5,919,703
Issued: July 6, 1999

Nucleic Acid Molecules Comprising the Prostate Specific Antigen (PSA) Promotor and Uses Thereof
Participating UCLA Researchers:
Shen Pang, Arie S. Belldegrun
This invention provides isolated or purified nucleic acid molecules comprising a prostate specific antigen (PSA) promotor alone or in combination with a cytomegalovirus (CMV) promoter. This can be used as a weapon against prostate cancer by using nucleic acid molecules with the PSA promotor to make prostate cancer cells sensitive to chemotherapeutic agents.
U.S. Patent No. 5,919,652
Issued: July 6, 1999

Anti-Microbial Targeting for Intracellular Pathogens
Participating UCLA Researchers:
Marcus A. Horwitz, Daniel L. Clemens
This invention is a method and composition for treating intracellular pathogens that reside in phagosomes. The compositions include antibiotics, which are conjugated with transferrin or other ligands to form conjugates that target membrane-bound pathogens. The antibiotic-transferrin conjugate is effective against pathogens, such as M. tuberculosis.
U.S. Patent No. 6,054,133
Issued: April 25, 2000

Intraluminal Directed Ultrasound Delivery device
Participating UCLA Researchers:
Hank H. Chen, Cheng Ji
This invention is an apparatus to destroy vascular occlusions. The ultrasound catheter consists of a coaxial cable of electric conductors with a piezoelectric element at its distal end. The piezoelectric element mechanically deforms in response and generates ultrasonic energy when the electric signal from the signal generator is connected to the electric conductor. The catheter is then brought to close proximity to the vascular occlusion and destroyed through sonophoresis.
U.S. Patent No. 6,024,718
Issued: February 15, 2000

Treatment of Cystic Disease with Compounds Which Stimulate TNF-a Production in VIVO
Participating UCLA Researchers:
David D.L. Woo
This invention provides for a method to treat polycystic kidney disease. A pharmacologically effective anti-cystic amount of TNF-a or an agent, which stimulates TNF-a production in vivo is administered to the mammal. Administration is intravenous, intraperitoneal, or intramuscular.
U.S. Patent No. 6,011,055
Issued: January 4, 2000

Leptospiral Outer Membrane Proteins
Participating UCLA Researchers:
David A. Haake
This invention is a method for purifying novel leptospiral outer membrane proteins from the Leptospira species. The proteins, their immunogenic fragments, and antibodies capable of binding to them are useful for inducing an immune response to the pathogenic Leptospira species as well as providing a diagnostic target for leptospirosis.
U.S. Patent No. 5,989,547
Issued: November 23, 1999

Isotope Separation Using a High Field Source and Improved Collectors
Participating UCLA Researchers:
Alfred Y. Wong, Glenn B. Rosenthal
This invention is an improvement on the plasma chamber having a source region and an enrichment region contained within the plasma chamber. The source region is provided with a plasma source for producing the plasma. The improvement consists of a magnet assembly for creating a shaped magnetic field in the plasma chamber so the shaped field provides a higher magnetic field intensity in the source region than in the enrichment area.
U.S. Patent No. 5,981,955
Issued: November 9, 1999

Diffusion-Based Method and Apparatus for Determining Circuit Interconnect Voltage Response
Participating UCLA Researchers:
Andrew B. Kahng, Sudhakar Muddu
This invention provides a novel method and apparatus for determining the voltage response as a function of time at a remote terminal within a very large scale integration (VLSI) circuit design using a known voltage input. VLSI circuit chips are commonplace in microprocessors.
U.S. Patent No. 6,047,117
Issued: April 4, 2000

Video Data Representation of Physiological Data
Participating UCLA Researchers:
Edward Wahl, Bernard B. Churchill
This invention provides a method for patient diagnostic testing which includes physiological data output in a two dimensional graphical format. The display data include bladder capacity information, pressure characteristics, and data as a function of volume such that bladder volume is indicated.
U.S. Patent No. 6,001,060
Issued: December 14, 1999

Tumor Radiosensitization Using Gene Therapy
Participating UCLA Researchers:
William H. McBride
This invention provides a method of radiosensitizing a tumor in a subject by contacting the tumor with a cytokine or a nucleic acid molecule encoding a cytokine. The tumor can also be radiosensitized by administering to the subject a cell genetically modified to express a cytokine at a site other than the tumor.
U.S. Patent No. 6,051,218
Issued: April 18, 2000

Clavanins
Participating UCLA Researchers:
Robert I. Lehrer, Sylvia L. Harwig, Chengquan Zhao, and In-Hee Lee
This invention relates to a class of peptides and peptide-like compounds, the clavanins which exhibit a broad range of antimicrobial activity. They are useful in preserving materials otherwise susceptible to microbial degradation. Clavanins have the ability to inhibit the growth of, destroy, or otherwise impede the undesired destructive effects of baterial infection in plants and bacterial, viral, and fungal infection in animals.
U.S. Patent No. 6,010,876
Issued: January 4, 2000
U.S. Patent No. 6,040,293
Issued: March 21, 2000

Immunoglobulin Trans-spliced Transcripts and Uses Thereof
Participating UCLA Researchers:
Andrew Saxon, Ke Zhang, and Shigeharu Fujieda
This invention provides for methods for directing the synthesis of a particular human immunoglobulin isotype. Specifically methods for treatment of disorders mediated by IgM, IgG, IgA, or IgE are provided. Inhibition of IgE synthesis is helpful for patients suffering from allergy disorders.
U.S. Patent No. 6,030,830
Issued: February 29, 2000

Bromocriptine for the Treatment of Alcoholics Diagnosed with the D2 Dopamine Receptor DRD2 A1 Allele
Participating UCLA Researchers:
Ernest P. Noble
This invention relates to dopamine agonist and opioidergic compositions and methods for their use in the treatment of alcoholism. Therapeutic kits and compounds in treating alcoholics having the A1 allele of the dopamine receptor D2 gene are disclosed as well as methods of treating alcoholics having the A1/A1 or A1/A2 DRD2 genotype comprising administration of dopamine agonists.
U.S. Patent No. 6,001,848
Issued: December 14, 1999

Externally Targeted Prophylactic and Chemotherapeutic Method and Agents
Participating UCLA Researchers:
Marcus A. Horwitz, Gunter Harth
This invention provides for the associated compositions and methods for effectively treating mammalian disease conditions caused by infection by pathogenic organisms. The extracellular enzymes necessary for the growth or survival of pathogenic organisms are identified.
U.S. Patent No. 6,013,660
Issued: January 11, 2000

Ataxia-Telangiectasia: Mutations in the ATM Gene
Participating UCLA Researchers:
Richard A. Gatti
Nucleic acid fragments having complementarity or identity to a mutation in the ataxia-telangiectasia mutated (ATM) gene are isolated and purified. Ataxia-telangiectasia (AT) is an autosomal recessive disorder characterized by progressive cerebellar ataxia, immunodeficiency, chromosomal instability, cancer susceptibility, and radiation sensitity.
U.S. Patent No. 5,955,279
Issued: September 21, 1999

Diagnosis, Prevention and Treatment of Ulcerative Colitis, and Clinical Subtypes Thereof, Using Microbial UC Panca Antigens
Participating UCLA Researchers:
Jonathan Braun, Offer Cohavy
Awaiting approval of invention description
U.S. Patent No. 6,074,835
Issued: June 13, 2000
This invention provides a method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease by obtaining a sample from that subject. The sample is then contacted with a histone H1-like antigen, or pANCA-reactive fragment thereof. The invention also provides for a technique to induce tolerance in a pANCA-positive patient with UC by administering an effective dose of a histone-like H1 antigen or tolerogenic fragment thereof.
U.S. Patent No. 6,033,864
Issued: March 7, 2000

Solid State Synthesis - CGN
Participating UCLA Researchers:
Richard B. Kaner, Charles H. Wallace
This invention provides a process for forming high quality crystalline refractory materials, particulary gallium (III) nitride (GaN) from solid precursors.
U.S. Patent No. 6,096,282
Issued: August 1, 2000

Transmembrane Protein
Participating UCLA Researchers:
Robert E. Reiter, Charles L. Sawyers, Owen N. Witte
This invention provides a human E25a protein that is unregulated in cancerous cells, including those of hormone refractory prostate cancer, colon cancer, breast cancer or other cancers of epithelial origin.
U.S. Patent No. 6,093,800
Issued: July 25, 2000

Method of Screnning Compounds for Controlling Capacitative Calcium Ion Entry into Mamalian Cells
Participating UCLA Researchers:
Lutz Birnbaumer, Xi Zhu
Two trp proteins from human cells (Htrp1 and Htrp2) are isolated and the trp proteins have been determined to be reponsible for and essential to the capacitative calcium ion entry (CCE) mechanism found in mammalian cells. This discovery provides a method to control calcium ion levels in cells by regulating the expression of biologically active trp proteins.
U.S. Patent No. 5,932,417
Issued: August 3, 1999

Clavaspirins
Participating UCLA Researchers:
Robert I. Lehrer, In-Hee Lee, and Chengquan Zhao
This invention relates to the discovery of a class of peptides and peptide-like compounds, the clavaspirins, that are useful in preserving the materials susceptible to microbial degradation, in protecting plants from bacterial infection, and in therapeutic and prophylactic protection of animals against bacteria, fungi, and viruses.
U.S. Patent No. 5,998,374
Issued: December 7, 1999

Enhanced Opening of Abnormal Brain Tissue Capillaries
Participating UCLA Researchers:
Keith L. Black
This invention provides for methods and compositions useful in selectively introducing pharmaceutical or diagnostic agents into abnormal brain tissue. Specifically this invention involves methods and compositions to selectively increase the permeability of the blood-brain barrier in abnormal brain tissue. This allows for direct delivery of pharmaceutical or diagnostic agents to such abnormal tissue.
U.S. Patent No. 6,043,223
Issued: March 28, 2000

Improved Methods for the Diagnosis and Treatment of Insulin Dependent Diabetes Mellitus
Participating UCLA Researchers:
Daniel L. Kaufman, Jide Tian
This invention provides for methods for detecting the status of an insulin-dependent diabetes mellitus (IDDM)-associated autoimmune response in a mammal. The methods may be employed prior to the onset of the clinical symptoms of the disease or subsequent to pancreatic tissue transplantation.
U.S. Patent No. 6,022,697
Issued: February 8, 2000

Apparatus for Testing for Infection By a Retrovirus
Participating UCLA Researchers:
Scott P. Layne, Tony J. Beugelsdijk
This invention provides an apparatus to test specimens for infection by a retrovirus. The apparatus consists of a process controller including a communications module for translating user commands into test instrument suite commands and a technique for communicating specimen test results to a user.
U.S. Patent No. 5,925,514
Issued: July 20, 1999

Apparatus for Automated Testing for Biological Specimens
Participating UCLA Researchers:
Scott P. Layne, Tony J. Beugelsdijk
This invention provides an apparatus for performing automated testing of infectious biological specimens. The apparatus consists of a process controller for translating user commands into test instrument suite commands. Included also is a test instrument suite for treating the specimen to manifest an observable result and a detector for measuring the observable result to generate specimen test results.
U.S. Patent No. 5,968,731
Issued: October 19, 1999

Breath Analysis For H Pylon
Participating UCLA Researchers:
Jonathan Kaunitz
This invention provides a method and system for measuring the relative concentrations of first and second isotopic forms of a chemical species within a sample.
U.S. Patent No. 5,957,858
Issued: September 28,1999

Error Prevention Method for Multimedia
Participating UCLA Researchers:
John D. Villasenor, Max Luttrell
This invention provides for a method of protecting errors from occurring during the decoding of plurality packets in multimedia. This method permits one to obtain constant channel throughput in a channel containing burst errors, a channel containing random errors, and a channel in which two types of error patterns coexist simultaneously.
U.S. Patent No. 5,954,839
Issued: September 21, 1999

Ion-Selective Membrane Sensors with Mercuracarborand Ionophore
Participating UCLA Researchers:
Leonidas G. Bachas
This invention discloses ion-selective membranes, which are suitable for use in ion-selective sensors. The membranes include a mercuracarbonated ionophore. The ion-selective membranes may be used in various ion sensors including ion-selective membrane electrodes.
U.S. Patent No. 5,985,117
Issued: November 16, 1999

Endovascular Device for Hyperthermia and Angioplasty and Method for Using the Same
Participating UCLA Researchers:
Guido Guglielmi, Cheng Ji
This invention provides for a method of treating hyperthermic tissue such as cancer tumors. An ohmic heating element on the distal tip of a catheter is inserted upstream on the tissue. Electrical power is provided to the helical coil heater for a selected time and degree. The tissue is therefore exposed to a controlled amount of heat at a selected temperature for a determined period of time.
U.S. Patent No. 6,011,995
Issued: January 4, 2000

Method and Apparatus for Endovascular Thermal Thrombosis and Thermal Cancer Treatment
Participating UCLA Researchers:
Guido Guglielmi, Cheng Ji
This invention provides for a means for endovascular heating of blood for purposes of promoting thrombosis in aneurysms, thrombosis in arteriovenous malformations or fistulas, and thermally heating blood in a tumor for consequent destruction of tumoral cells.
U.S. Patent No. 5,919,187
Issued: July 6, 1999

Transferrin Receptor Specific Ligands
Participating UCLA Researchers:
Sherie L. Morrison
This invention provides a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain of a host. A therapeutically effective amount of a ligand-neuropharmaceutical agent fusion protein is administered to the host where the ligand is reactive with a brain capillary endothelial cell receptor.
U.S. Patent No. 5,977,307
Issued: November 2, 1999